Description
This modified 44-amino acid GHRH analog incorporates a trans-3-hexenoic acid moiety at the N-terminus, enhancing enzymatic stability while maintaining high-affinity GHRH receptor engagement. It serves as a specialized reagent for studying GH-mediated metabolic effects with emphasis on adipose tissue remodeling. For research use only.
- Visceral Adipose Remodeling: Investigated for selective reduction of trunk fat mass via GH-mediated activation of hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) pathways.
- Hepatic IGF-1 Stimulation: Studied for dose-dependent upregulation of circulating IGF-1 and its downstream effects on protein synthesis via the mTOR-p70S6K axis.
- Somatotroph Receptor Pharmacology: Explored as a tool for characterizing GHRH-R desensitization kinetics and tachyphylaxis thresholds in prolonged exposure protocols.









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